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UNSERE GEN-ANALYSE

Stress-spezifische Gene sind besonders wichtig

Unser genetisches Programm untersucht 14 verschiedene Gene, die besonders dann relevant sind, wenn Menschen dauerhaft Stressbelastungen ausgesetzt sind. Strukturelle Veränderungen dieser Gene, sogenannte Polymorphismen, können ganz wesentlich zur Entwicklung chronischer Stresserkrankungen beitragen.

Prävention und Therapie sind möglich

Die Kenntnis solcher Polymorphismen ist sowohl für die Prävention als auch für die Behandlung chronischer Stresserkrankungen von enormer Bedeutung. Sie ermöglicht Ihnen, der Entstehung solcher Erkrankungen entgegenzuwirken und sie weit effektiver zu behandeln.

Bundesweit einzigartige Zusammensetzung des stress-spezifischen Gen-Programms
50% unter dem üblichen Preisniveau
Wissenschaftlich fundierte Befunderstellung
Inkl. Individueller laborchemischer Empfehlungen
Inkl. Individueller therapeutischer Empfehlungen
Jahrzehntelange Erfahrung in Stressmedizin und Genetik
Ergänzendes Glossar der genetischen Fachbegriffe
Vielfältige Veröffentlichungen zu stressmedizinischen Fragestellungen

VORGEHENSWEISE

VORGEHENSWEISE

VORGEHENSWEISE

Das aus 3 Teilen bestehende Gesamtpaket umfasst die Untersuchung von 14 Genen mit der Fragestellung:

Sind Sie aufgrund Ihrer genetischen Veranlagung anfälliger für Stress und dessen körperliche Auswirkungen?

Können Sie sich ausreichend gegenüber toxischen Sauerstoffradikalen schützen?

Haben Sie Probleme beim Abbau giftiger Substanzen?

Genetische Variationen aus diesen 3 Gruppen können das Risiko, ernsthafte, chronische Stress-Erkrankungen zu entwickeln, erheblich erhöhen. Näheres dazu finden Sie weiter unten, unter „Zur Detailansicht".

Genanalyse McMind Gesamtpaket

Gesamtpaket Gen-Analyse

*Neukunden erhalten einen Rabatt von 10%

Genanalyse McMind Gesamtpaket

Gesamtpaket Gen‐Analyse

*Neukunden erhalten einen Rabatt von 10%

Genanalyse McMind Gesamtpaket

Gesamtpaket Gen-Analyse

*Neukunden erhalten einen Rabatt von 10%

WISSENSCHAFTLICHE LITERATUR

COMT

1. (PDF) Catechol-O-Methyltransferase and Cardiovascular Disease: MESA (researchgate.net)

2. Association of Catechol-O-methyltransferase (COMT Val 158 Met) with future risk of cardiovascular disease in depressed individuals - a Swedish population-based cohort study - PubMed (nih.gov)

3. Potential Impact of COMT-rs4680 G > A Gene Polymorphism in Coronary Artery Disease - PubMed (nih.gov)

4. The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes - PubMed (nih.gov)

5. Catechol- O-methyltransferase Val 158 Met Genotype and Early-Life Family Adversity Interactively Affect Attention-Deficit Hyperactivity Symptoms Across Childhood - PubMed (nih.gov)

6. Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA - PubMed (nih.gov)

7. Genetically based reduced MAOA and COMT functioning is associated with the cortisol stress response: a replication study - PubMed (nih.gov)

MAO-A

1. Association of monoamine oxidase A (MAOA) polymorphisms and clinical subgroups of major depressive disorders in the Han Chinese population - PubMed (nih.gov)

2. Association of MAOA genetic variants and resilience with psychosocial stress: A longitudinal study of Syrian refugees - PubMed (nih.gov)

3. Monoamine oxidase is a source of oxidative stress in obese patients with chronic inflammation 1 - PubMed (nih.gov)

4. Moderator Effects of Life Stress on the Association between MAOA-uVNTR, Depression, and Burnout - PubMed (nih.gov)

GR

1. Methylation of the glucocorticoid receptor gene associated with depression in patients with acute coronary syndrome - PubMed (nih.gov)

2. NR3C1 hypermethylation in depressed and bullied adolescents - PubMed (nih.gov)

3. Interactive influence of sex, stressor timing, and the BclI glucocorticoid receptor polymorphism on stress-induced alterations of long-term memory - PubMed (nih.gov)

4. Glucocorticoid receptor DNA methylation and childhood trauma in chronic fatigue syndrome patients - PubMed (nih.gov)

5. The NR3C1 gene expression is a potential surrogate biomarker for risk and diagnosis of posttraumatic stress disorder - PubMed (nih.gov)

FKBP5

1. Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB-driven inflammation and cardiovascular risk - PubMed (nih.gov)

2. Association between FKBP5 polymorphisms and depressive disorders or suicidal behavior: A systematic review and meta-analysis study - PubMed (nih.gov)

3. Allele-specific DNA methylation level of FKBP5 is associated with post-traumatic stress disorder - PubMed (nih.gov)

4. Type 2 diabetes and cardiometabolic risk may be associated with increase in DNA methylation of FKBP5 - PubMed (nih.gov)

5. Interaction between FKBP5 gene and childhood trauma on psychosis, depression and anxiety symptoms in a non-clinical sample - PubMed (nih.gov)

6. Influence of FKBP5 polymorphism and DNA methylation on structural changes of the brain in major depressive disorder - PubMed (nih.gov)

7. FKBP5 polymorphism is associated with insulin resistance in children and adolescents with obesity - PubMed (nih.gov)

8. The glucocorticoid receptor-FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder - PubMed (nih.gov)

BDNF

1. New insights on brain-derived neurotrophic factor epigenetics: from depression to memory extinction - PubMed (nih.gov)

2. Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity - PubMed (nih.gov)

3. BDNF Val66Met polymorphism is associated with HPA axis reactivity to psychological stress characterized by genotype and gender interactions - PubMed (nih.gov)

4. Low brain-derived neurotrophic factor protein levels and single-nucleotide polymorphism Val66Met are associated with peripheral neuropathy in type II diabetic patients - PubMed (nih.gov)

5. The Relationships Between Stress, Mental Disorders, and Epigenetic Regulation of BDNF - PubMed (nih.gov)

6. BDNF Val⁶⁶Met polymorphism to generalized anxiety disorder pathways: Indirect effects via attenuated parasympathetic stress-relaxation reactivity - PubMed (nih.gov)

7. Brain-Derived Neurotrophic Factor and Diabetes - PubMed (nih.gov)

8. Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease - PubMed (nih.gov)

9. The implication of BDNF Val66Met polymorphism in progression from subjective cognitive decline to mild cognitive impairment and Alzheimer's disease: a 9-year follow-up study - PubMed (nih.gov)

10. Interaction of BDNF and cytokines in executive dysfunction in patients with chronic schizophrenia - PubMed (nih.gov)

11. Brain-derived neurotrophic factor downregulation in gastric cancer - PubMed (nih.gov)

12. Changes in the Brain-Derived Neurotrophic Factor Are Associated with Improvements in Diabetes Risk Factors after Exercise Training in Adolescents with Obesity: The HEARTY Randomized Controlled Trial - PubMed (nih.gov)

SOD2

1. Association between manganese superoxide dismutase (MnSOD) polymorphism and prostate cancer susceptibility: a meta-analysis - PubMed (nih.gov)

2. Can Melatonin Act as an Antioxidant in Hydrogen Peroxide-Induced Oxidative Stress Model in Human Peripheral Blood Mononuclear Cells? - PubMed (nih.gov)

3. SOD2 Facilitates the Antiviral Innate Immune Response by Scavenging Reactive Oxygen Species - PubMed (nih.gov)

4. ALA16VAL-MnSOD gene polymorphism and stroke: Association with dyslipidemia and glucose levels - PubMed (nih.gov)

5. SOD2 gene polymorphism and response of oxidative stress parameters in young wrestlers to a three-month training - PubMed (nih.gov)

6. Association between MnSOD Val16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls - PubMed (nih.gov)

7. Association between Genetic Polymorphisms in Superoxide Dismutase Gene Family and Risk of Gastric Cancer - PubMed (nih.gov)

GPX1

1. Relationship between Glutathione Peroxidase, Platelet Reactivity, and Reactive Oxygen Species in an Acute Coronary Syndrome Population - PubMed (nih.gov)

2. Pro198Leu Polymorphism in the Glutathione Peroxidase 1 Gene Contributes to Diabetic Peripheral Neuropathy in Type 2 Diabetes Patients - PubMed (nih.gov)

3. GPX1, a biomarker for the diagnosis and prognosis of kidney cancer, promotes the progression of kidney cancer - PubMed (nih.gov)

4. Association of GPX1 polymorphism, GPX activity and prostate cancer risk - PubMed (nih.gov)

NQO1

1. The NQO1 Pro187Ser polymorphism and breast cancer susceptibility: evidence from an updated meta-analysis - PubMed (nih.gov)

2. NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms - PubMed (nih.gov)

3. NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places - PubMed (nih.gov)

4. Functions of NQO1 in Cellular Protection and CoQ 10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch - PubMed (nih.gov)

5. Implications of NQO1 in cancer therapy - PubMed (nih.gov)

6. Alzheimer's Disease and NQO1: Is there a Link? - PubMed (nih.gov)

7. Tumor Suppressive Function of NQO1 in Cutaneous Squamous Cell Carcinoma (SCC) Cells - PubMed (nih.gov)

8. [Association of NQO1 Polymorphism with Multiple Myeloma Risk in Koreans] - PubMed (nih.gov)

9. [NQ01 gene polymorphism C609T associated with an increased risk for cognitive dysfunction and sporadic Alzheimer's disease in Chinese] - PubMed (nih.gov)

MTHFR

1. Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis - PubMed (nih.gov)

2. Life-threatening course in coronavirus disease 2019 (COVID-19): Is there a link to methylenetetrahydrofolic acid reductase (MTHFR) polymorphism and hyperhomocysteinemia? - PubMed (nih.gov)

3. MTHFR polymorphisms (rs1801133) and systemic lupus erythematosus risk: A meta-analysis - PubMed (nih.gov)

4. Methylenetetrahydrofolate reductase genetic polymorphism and the risk of diabetic nephropathy in type 2 diabetic patients - PubMed (nih.gov)

5. Hyperhomocysteinemia is Associated with Inflammation, Bone Resorption, Vitamin B12 and Folate Deficiency and MTHFR C677T Polymorphism in Postmenopausal Women with Decreased Bone Mineral Density - PubMed (nih.gov)

6. Interaction of serum vitamin B 12 and folate with MTHFR genotypes on risk of ischemic stroke - PubMed (nih.gov)

7. Association of MTHFR gene polymorphisms with pancreatic cancer: meta-analysis of 17 case-control studies - PubMed (nih.gov)

8. Sex-specific effects of methylenetetrahydrofolate reductase polymorphisms on schizophrenia with methylation changes - PubMed (nih.gov)

9. C677T polymorphism increases the risk of early spontaneous abortion - PubMed (nih.gov)

10. Association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and lung cancer risk in Chinese people: An updated meta-analysis - PubMed (nih.gov)

MAO-B

1. Association between monoamine oxidase B A644G polymorphism and Parkinson's disease risk: a meta-analysis in the Chinese population - PubMed (nih.gov)

2. Genetic variants of MAOB affect serotonin level and specific behavioral attributes to increase autism spectrum disorder (ASD) susceptibility in males - PubMed (nih.gov)

3. Monoamine oxidase B gene variants associated with attention deficit hyperactivity disorder in the Indo-Caucasoid population from West Bengal - PubMed (nih.gov)

4. A meta-analysis on relationship of MAOB intron 13 polymorphisms, interactions with smoking/COMT H158L polymorphisms with the risk of PD - PubMed (nih.gov)

5. The relationship between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease risk: a meta-analysis - PubMed (nih.gov)

6. Functional monoamine oxidase B gene intron 13 polymorphism predicts putaminal dopamine turnover in de novo Parkinson's disease - PubMed (nih.gov)

7. Monoamine Oxidase B Expression Correlates with a Poor Prognosis in Colorectal Cancer Patients and Is Significantly Associated with Epithelial-to-Mesenchymal Transition-Related Gene Signatures - PubMed (nih.gov)

GSTM1

1. Association of glutathione S-transferase M1 polymorphisms in the colorectal cancer risk: A meta-analysis - PubMed (nih.gov)

2. The influence of polymorphic GSTM1 gene on the increased susceptibility of non-viral hepatic cirrhosis: evidence from observational studies - PubMed (nih.gov)

3. Role of Donors and Recipients' Glutathione S-Transferase Gene Polymorphisms in Association of Oxidative Stress With Delayed Graft Function in Kidney Allograft Recipients - PubMed (nih.gov)

4. Glutathione S-transferase M1 null genotype, household pesticides exposure and cutaneous melanoma - PubMed (nih.gov)

5. Glutathione S-transferase polymorphisms influence chemotherapy response and treatment outcome in breast cancer - PubMed (nih.gov)

6. The association of GSTM1 deletion polymorphism with lung cancer risk in Chinese population: evidence from an updated meta-analysis - PubMed (nih.gov)

7. Glutathione S-transferase M1 modulates allergen-induced NF-κB activation in asthmatic airway epithelium - PubMed (nih.gov)

8. Meta-analysis of GSTM1 null genotype and lung cancer risk in Asians - PubMed (nih.gov)

9. GSTM1-null allele predicts rapid disease progression in nondialysis patients and mortality among South Indian ESRD patients - PubMed (nih.gov)

10. Association of Glutathione S-Transferase M1 null genotype with inflammatory bowel diseases: A systematic review and meta-analysis - PubMed (nih.gov)

GSTT1

1. An updated meta-analysis of the relationship between glutathione S-transferase T1 null/presence gene polymorphism and the risk of lung cancer - PubMed (nih.gov)

2. Genetic Polymorphisms of Xenobiotic Metabolizing Genes (GSTM1, GSTT1, GSTP1), Gene-Gene Interaction with Association to Lung Cancer Risk in North India; A Case Control Study - PubMed (nih.gov)

3. Expression of Gstt1 in Type 2 Diabetic Retinopathy Patients - PubMed (nih.gov)

4. Glutathione S-Transferase T1 Null Genotype is Associated with Susceptibility to Inflammatory Bowel Disease - PubMed (nih.gov)

5. Genetic Determinants of 1,3-Butadiene Metabolism and Detoxification in Three Populations of Smokers with Different Risks of Lung Cancer - PubMed (nih.gov)

6. GSTT1 (rs4025935) null genotype is associated with increased risk of sickle cell disease in the populations of Tabuk-Northwestern region of Saudi Arabia - PubMed (nih.gov)

7. Glutathione S-Transferase T1 (GSTT1) Null Polymorphism, Smoking, and Their Interaction in Coronary Heart Disease: A Comprehensive Meta-Analysis - PubMed (nih.gov)

8. Association of the Glutathione S-transferase T1 Null Genotype with Risk of Gastric Cancer: a Meta-analysis in Asian Populations - PubMed (nih.gov)

9. Null genotype of GSTT1 contributes to increased Parkinson's disease risk in Caucasians: evidence from a meta-analysis - PubMed (nih.gov)

10. GSTT1 polymorphism and the risk of developing prostate cancer - PubMed (nih.gov)

11. Association of the GSTT1 polymorphism in upper aerodigestive tract cancer with tobacco smoking - PubMed (nih.gov)

GSTP1

1. Glutathione S-Transferase Pi 1 (GSTP1) Gene 313 A/G (rs1695) polymorphism is associated with the risk of urinary bladder cancer: Evidence from a systematic review and meta-analysis based on 34 case-control studies - PubMed (nih.gov)

2. The Relation between Polymorphisms in Exon 5 and Exon 6 of GSTP1 Gene and the Risk of Lung Cancer in Iranian People - PubMed (nih.gov)

3. An updated meta-analysis for association of glutathione S-transferase P1 gene polymorphism with the susceptibility of lung cancer - PubMed (nih.gov)

4. Genetic Variation in GSTP1, Lung Function, Risk of Lung Cancer, and Mortality - PubMed (nih.gov)

5. GSTP1 Loss results in accumulation of oxidative DNA base damage and promotes prostate cancer cell survival following exposure to protracted oxidative stress - PubMed (nih.gov)

6. Association analysis of rs1695 and rs1138272 variations in GSTP1 gene and breast cancer susceptibility - PubMed (nih.gov)

7. GSTP1 rs1138272 Polymorphism Affects Prostate Cancer Risk - PubMed (nih.gov)

NAT2

1. Association between NAT2 polymorphisms and acute leukemia risk: A meta-analysis - PubMed (nih.gov)

2. N-acetyltransferase 2 gene polymorphisms are associated with susceptibility to cancer: a meta-analysis - PubMed (nih.gov)

3. N-acetyltransferase-2 gene polymorphisms and prostate cancer susceptibility in Latin American patients - PubMed (nih.gov)

4. N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer - PubMed (nih.gov)